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Russian Military Medical
ORIGINAL ARTICLES Vol. 41 (4) 2022 Academy Reports
386
DOI: https://doi.org/10.17816/rmmar111944
Research Article
Effects of human lactoferrin under conditions

of neurotoxic exposure: experimental research

Marina Yu. Kopaeva, Anton B. Cherepov, Irina Yu. Zarayskaya
National Research Center “Kurchatov Institute”, Moscow, Russia
BACKGROUND: Translational research using laboratory animals aimed at revealing the features of the pathogenesis of
Parkinson’s disease serve as a tool for finding new therapeutic strategies.
AIM: Was to investigate the effects of human lactoferrin (a multifunctional globular glycoprotein) on behavior the
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice as the model of dopaminergic neurons loss.
MATERIALS AND METHODS: Nigrostriatal dopaminergic injury was induced by single administration of 1-methyl-4-phe-
nyl-1,2,3,6-tetrahydropyridine (40 mg/kg) to five-month-old C57Bl/6 mice. Behavioral functions were assessed in the open
field and rotarod tests and by the stride length analysis.
RESULTS: Preliminary administration of lactoferrin resulted in a significant reduction in the severity of nervous sys-
tem lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The positive effect of lactoferrin on the exploratory
behavior of animals disturbed by neurotoxin, depending on the time of administration, was revealed. Exogenous protein
with double preliminary administration had a protective effect on the change in body weight of mice after acute 1-methyl-
4-phenyl-1,2,3,6-tetrahydropyridine exposure. This suggests a reduction in systemic toxic effects against the background
of lactoferrin therapy.
CONCLUSION: The results obtained indicate the possibility of the potential use of lactoferrin as a promising therapeutic
agent in the treatment of neurodegenerative diseases.
Keywords: Parkinson’s disease; dopaminergic neurons; exploratory activity; neurodegeneration; neurotoxin MPTP;
rotarod; open field test; human lactoferrin.

To cite this article:
Kopaeva MYu, Cherepov AB, Zarayskaya IYu. Effects of human lactoferrin under conditions of neurotoxic exposure: experimental research.
Russian Military Medical Academy Reports. 2022;41(4):385–392. DOI: https://doi.org/10.17816/rmmar111944

Received: 17.10.2022 Accepted: 20.10.2022 Published: 17.11.2022

The article can be used under the CC BY-NC-ND 4.0 license
© Authors, 2022