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Russian Military Medical
ORIGINAL ARTICLES Vol. 41 (4) 2022 Academy Reports
400
DOI: https://doi.org/10.17816/rmmar111887
Research Article
Comparison of the state of brain metabolism

and psycho emotional disorders in patients

with postmastectomy syndrome

Albina M. Makhanova, Maria L. Pospelova, Daria V. Ryzhkova, Tatiana M. Alexeeva,
Olga V. Fionik, Varvara V. Krasnikova, Samwel N. Tonyan, Alexandra E. Nikolaeva,
Tatyana A. Bukkieva, Egor A. Mokin, Mark S. Voynov, Matvey I. Laptev, Ekaterina E. Vyalykh
Personalized Medicine Centre, Almazov National Medical Research Centre, Saint Petersburg, Russia

BACKGROUND: The most common consequence of radical treatment of breast cancer is postmastectomy syndrome —
a complex of changes in the lymphocirculatory system, central and peripheral nervous system, skeletal and muscular ap-
paratus, that significantly reduce the quality of life and working capacity of women. In recent years, special attention has
been paid to the study of psycho emotional disorders in this group of patients. A promising method for preclinical diagnosis
of anxiety and depressive disorders in patients with postmastectomy syndrome may be positron emission computed to-
mography with fluorine-18 labeled glucose — 2(18F)-fluoro-2-deoxy-D-glucose, which makes it possible to deduce typical
patterns of changes in glucose metabolism in cerebral structures in various depressive and anxiety states.
AIM: The purpose of this study is to study the relationship between brain metabolism and psycho emotional status
in patients with postmastectomy syndrome.
MATERIALS AND METHODS: In our work, the sample consisted of 28 patients who underwent radical treatment for
breast cancer, who underwent an assessment of the psycho-emotional state using the State-Trait Anxiety Inventory and
Zung scales for self-assessment of depression. Positron emission tomography was also performed with 18-fluorodeoxy-
glucose.
RESULTS: The study revealed that 71% of patients showed an increased level of anxiety, 64% showed signs of de-
pression. Positron emission tomography data revealed the following areas of hypometabolism in patients with anxiety-
depressive disorders: parietal cortex, inferior parietal lobule, precuneus, superior temporal gyrus, prefrontal cortex,
posterior cingulate cortex.
CONCLUSION: Thus, typical zones of changes in glucose metabolism in patients with psycho emotional disorders have
been identified, which makes it possible to improve the accuracy of diagnosing these conditions, as well as to develop the
most effective ways to prevent and treat them.
Keywords: anxiety; brain metabolism; depression; PET; postmastectomy syndrome; prognosis.
To cite this article:
Makhanova AM, Pospelova ML, Ryzhkova DV, Alexeeva TM, Fionik OV, Krasnikova VV, Tonyan SN, Nikolaeva AE, Bukkieva TA, Mokin EA,
Voynov MS, Laptev MI, Vyalykh EE. Comparison of the state of brain metabolism and psycho emotional disorders in patients with postmastectomy
syndrome. Russian Military Medical Academy Reports. 2022;41(4):399–406. DOI: https://doi.org/10.17816/rmmar111887

Received: 12.10.2022 Accepted: 14.10.2022 Published: 17.11.2022

The article can be used under the CC BY-NC-ND 4.0 license
© Authors, 2022