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Russian Military Medical
SCIENTIFIC REVIEWS Vol. 41 (4) 2022 Academy Reports
440
DOI: https://doi.org/10.17816/rmmar111854
Review Article
Role of short-chain fatty acids in the pathogenesis

of Parkinson’s disease

2
1
1, 2
Igor V. Krasakov , Igor V. Litvinenko , Gennadiy G. Rodionov ,
2
2
Nataliya I. Davydova , Sergey S. Aleksanin , Ekaterina V. Svetkina 2
1 Military Medical Academy, Saint Petersburg, Russia;
2
Nikiforov All-Russian Center of Emergency and Radiation Medicine, Saint Petersburg, Russia
Parkinson’s disease is tightly related to enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain
fatty acids are the main metabolites produced by the gut bacteria fermentation of dietary fiber and are suggested to play
a key role in gut–brain cross-talk. The article presents a review of the literature on the contribution of short-chain fatty
acids to the pathogenesis of Parkinson’s disease. Patients with Parkinson’s disease have higher plasma concentrations of
acetate, propionate, and butyrate than controls. These changes correlate with the severity of the clinical picture of Parkin-
son’s disease, levels of pro-inflammatory gut bacteria and pro-inflammatory cytokines. The cause of these changes may
be an over-population of the gut of Parkinson’s disease patients with bacteria such as clostridia and ruminococci, leading
to regulatory immune reactions, intestinal inflammation, increased permeability of the intestinal barrier, excessive intake
primarily of propionate in the central nervous system, and activation of neuroinflammation. The importance of further study
of the relationship between changes in gut metabiotic, its metabolome, and the immune system T-cell in patients with
Parkinson’s disease is demonstrated. Justified the study of blood plasma from patients with Parkinson’s disease using gas
chromatography–mass spectrometry for the accurate, clinically relevant, assessment of the gut–brain crosstalk.

Keywords: gas chromatography–mass spectrometry; gut microbiota; metabolome; neuroinflammation; Parkinson’s disease;
pathogenesis; short-chain fatty acids.

To cite this article:
Krasakov IV, Litvinenko IV, Rodionov GG, Davydova NI, Aleksanin SS , Svetkina EV. Role of short-chain fatty acids in the pathogenesis of Parkinson’s disease.
Russian Military Medical Academy Reports. 2022;41(4):439–444. DOI: https://doi.org/10.17816/rmmar111854

Received: 12.10.2022 Accepted: 19.10.2022 Published: 17.11.2022

The article can be used under the CC BY-NC-ND 4.0 license
© Authors, 2022